clvs1 protein (Callorhinchus milii) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

clvs1

CRAL-TRIO domain-containing protein. (331 aa)

Predicted Functional Partners:

cltcl1

0.480

cltc

0.480

ankfy1

0.460

sec63

0.446

LOC103191386

0.440

ap1g1

0.440

rdh10

0.419

LOC103172782

0.419

sdr16c5

0.419

mkln1

0.412

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103172782	clvs1	ENSCMIP00000029113	ENSCMIP00000046168	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	CRAL-TRIO domain-containing protein.	0.419
LOC103172782	rdh10	ENSCMIP00000029113	ENSCMIP00000004067	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.901
LOC103191386	ap1g1	ENSCMIP00000034434	ENSCMIP00000036867	AP-1 complex subunit gamma.	AP-1 complex subunit gamma.	0.901
LOC103191386	cltc	ENSCMIP00000034434	ENSCMIP00000045968	AP-1 complex subunit gamma.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.898
LOC103191386	cltcl1	ENSCMIP00000034434	ENSCMIP00000033221	AP-1 complex subunit gamma.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.898
LOC103191386	clvs1	ENSCMIP00000034434	ENSCMIP00000046168	AP-1 complex subunit gamma.	CRAL-TRIO domain-containing protein.	0.440
ankfy1	clvs1	ENSCMIP00000025434	ENSCMIP00000046168	Uncharacterized protein.	CRAL-TRIO domain-containing protein.	0.460
ap1g1	LOC103191386	ENSCMIP00000036867	ENSCMIP00000034434	AP-1 complex subunit gamma.	AP-1 complex subunit gamma.	0.901
ap1g1	cltc	ENSCMIP00000036867	ENSCMIP00000045968	AP-1 complex subunit gamma.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.898
ap1g1	cltcl1	ENSCMIP00000036867	ENSCMIP00000033221	AP-1 complex subunit gamma.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.898
ap1g1	clvs1	ENSCMIP00000036867	ENSCMIP00000046168	AP-1 complex subunit gamma.	CRAL-TRIO domain-containing protein.	0.440
cltc	LOC103191386	ENSCMIP00000045968	ENSCMIP00000034434	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-1 complex subunit gamma.	0.898
cltc	ap1g1	ENSCMIP00000045968	ENSCMIP00000036867	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-1 complex subunit gamma.	0.898
cltc	cltcl1	ENSCMIP00000045968	ENSCMIP00000033221	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
cltc	clvs1	ENSCMIP00000045968	ENSCMIP00000046168	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	CRAL-TRIO domain-containing protein.	0.480
cltcl1	LOC103191386	ENSCMIP00000033221	ENSCMIP00000034434	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-1 complex subunit gamma.	0.898
cltcl1	ap1g1	ENSCMIP00000033221	ENSCMIP00000036867	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-1 complex subunit gamma.	0.898
cltcl1	cltc	ENSCMIP00000033221	ENSCMIP00000045968	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
cltcl1	clvs1	ENSCMIP00000033221	ENSCMIP00000046168	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	CRAL-TRIO domain-containing protein.	0.480
clvs1	LOC103172782	ENSCMIP00000046168	ENSCMIP00000029113	CRAL-TRIO domain-containing protein.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.419

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007017

Microtubule-based process

8 of 721

1.33

1.67

3.08e-06

GO:0010970

Transport along microtubule

4 of 115

1.83

1.36

0.0017

GO:0032402

Melanosome transport

2 of 11

2.55

0.8

0.0349

GO:1902850

Microtubule cytoskeleton organization involved in mitosis

3 of 109

1.73

0.75

0.0349

GO:0051650

Establishment of vesicle localization

3 of 122

1.68

0.74

0.0349

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005869

Dynactin complex

6 of 15

2.89

6.79

1.52e-13

GO:0005875

Microtubule associated complex

9 of 144

2.08

5.8

3.45e-15

GO:0030286

Dynein complex

4 of 58

2.13

2.63

4.76e-06

GO:0005813

Centrosome

8 of 554

1.45

2.28

1.36e-08

GO:0000776

Kinetochore

4 of 127

1.78

1.88

7.64e-05

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36107127

(2022) Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin.

6 of 9

3.11

6.48

1.08e-12

PMID:36071160

(2022) Structure of dynein-dynactin on microtubules shows tandem adaptor binding.

3 of 9

2.81

1.81

0.00051

PMID:33734450

(2021) Cryo-EM reveals the complex architecture of dynactins shoulder region and pointed end.

3 of 8

2.86

1.81

0.00051

PMID:18437411

(2008) The mammalian centrosome and its functional significance.

3 of 18

2.51

1.45

0.0021

PMID:33523880

(2021) The Arp111 minifilament of dynactin primes the endosomal Arp23 complex.

3 of 22

2.42

1.38

0.0028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15025

Cytoplasmic dynein complex, and Dynactin complex

11 of 33

2.81

13.02

3.35e-27

CL:15064

Dynactin complex, and F-actin-capping protein subunit alpha/beta

9 of 12

3.16

12.32

5.81e-24

CL:15067

Dynactin complex

7 of 7

3.29

9.61

1.83e-18

CL:15029

Mixed, incl. Dynein light chain, type 1/2, conserved site, and Dynein family light intermediate chain

2 of 7

2.74

1.28

0.0048

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ssc04962

Vasopressin-regulated water reabsorption

7 of 39

2.54

6.83

1.47e-14

ssc05016

Huntington disease

7 of 260

1.72

3.12

2.35e-09

ssc05014

Amyotrophic lateral sclerosis

7 of 306

1.65

2.87

4.79e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

SSC-6811436

COPI-independent Golgi-to-ER retrograde traffic

10 of 39

2.7

10.96

2.74e-23

SSC-3371497

HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

10 of 40

2.68

10.92

2.74e-23

SSC-6807878

COPI-mediated anterograde transport

10 of 80

2.38

8.85

6.35e-21

SSC-2132295

MHC class II antigen presentation

10 of 119

2.21

7.6

1.63e-19

SSC-380259

Loss of Nlp from mitotic centrosomes

6 of 60

2.29

4.97

3.20e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005869

Dynactin complex

6 of 7

3.22

7.72

6.14e-15

GOCC:0005875

Microtubule associated complex

9 of 123

2.15

6.2

1.12e-15

GOCC:0015630

Microtubule cytoskeleton

10 of 593

1.51

3.0

2.21e-12

GOCC:0030286

Dynein complex

4 of 57

2.13

2.62

4.97e-06

GOCC:0005868

Cytoplasmic dynein complex

2 of 18

2.33

1.08

0.0102

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00132

Bacterial transferase hexapeptide (six repeats)

2 of 4

2.99

1.16

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011004

Trimeric LpxA-like superfamily

2 of 4

2.99

0.91

0.0225

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