pcsk2 protein (Callorhinchus milii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

pcsk2

Neuroendocrine convertase 2; Belongs to the peptidase S8 family. (644 aa)

Predicted Functional Partners:

scg5

0.850

cpe

0.680

ins

0.619

bsnd

0.619

usp24

0.581

zbtb24

0.578

b4galt5

0.571

epb41l2

0.561

ak7

0.561

zbtb46

0.539

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ak7	b4galt5	ENSCMIP00000040190	ENSCMIP00000031767	Uncharacterized protein.	Uncharacterized protein.	0.568
ak7	epb41l2	ENSCMIP00000040190	ENSCMIP00000024890	Uncharacterized protein.	FERM domain-containing protein.	0.538
ak7	pcsk2	ENSCMIP00000040190	ENSCMIP00000049063	Uncharacterized protein.	Neuroendocrine convertase 2; Belongs to the peptidase S8 family.	0.561
ak7	zbtb24	ENSCMIP00000040190	ENSCMIP00000035610	Uncharacterized protein.	Zinc finger and BTB domain-containing protein 24.	0.597
ak7	zbtb46	ENSCMIP00000040190	ENSCMIP00000027765	Uncharacterized protein.	Uncharacterized protein.	0.563
b4galt5	ak7	ENSCMIP00000031767	ENSCMIP00000040190	Uncharacterized protein.	Uncharacterized protein.	0.568
b4galt5	epb41l2	ENSCMIP00000031767	ENSCMIP00000024890	Uncharacterized protein.	FERM domain-containing protein.	0.545
b4galt5	pcsk2	ENSCMIP00000031767	ENSCMIP00000049063	Uncharacterized protein.	Neuroendocrine convertase 2; Belongs to the peptidase S8 family.	0.571
b4galt5	zbtb24	ENSCMIP00000031767	ENSCMIP00000035610	Uncharacterized protein.	Zinc finger and BTB domain-containing protein 24.	0.587
b4galt5	zbtb46	ENSCMIP00000031767	ENSCMIP00000027765	Uncharacterized protein.	Uncharacterized protein.	0.527
bsnd	pcsk2	ENSCMIP00000018570	ENSCMIP00000049063	Uncharacterized protein.	Neuroendocrine convertase 2; Belongs to the peptidase S8 family.	0.619
bsnd	usp24	ENSCMIP00000018570	ENSCMIP00000018764	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.552
cpe	ins	ENSCMIP00000003977	ENSCMIP00000017634	Uncharacterized protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.725
cpe	pcsk2	ENSCMIP00000003977	ENSCMIP00000049063	Uncharacterized protein.	Neuroendocrine convertase 2; Belongs to the peptidase S8 family.	0.680
epb41l2	ak7	ENSCMIP00000024890	ENSCMIP00000040190	FERM domain-containing protein.	Uncharacterized protein.	0.538
epb41l2	b4galt5	ENSCMIP00000024890	ENSCMIP00000031767	FERM domain-containing protein.	Uncharacterized protein.	0.545
epb41l2	pcsk2	ENSCMIP00000024890	ENSCMIP00000049063	FERM domain-containing protein.	Neuroendocrine convertase 2; Belongs to the peptidase S8 family.	0.561
epb41l2	zbtb24	ENSCMIP00000024890	ENSCMIP00000035610	FERM domain-containing protein.	Zinc finger and BTB domain-containing protein 24.	0.530
epb41l2	zbtb46	ENSCMIP00000024890	ENSCMIP00000027765	FERM domain-containing protein.	Uncharacterized protein.	0.527
ins	cpe	ENSCMIP00000017634	ENSCMIP00000003977	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.725