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STRINGSTRING
GRB2 protein (Latimeria chalumnae) - STRING interaction network
"GRB2" - Growth factor receptor-bound protein 2a in Latimeria chalumnae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRB2Growth factor receptor-bound protein 2a (292 aa)    
Predicted Functional Partners:
SHC1
SHC adaptor protein 1; SHC (Src homology 2 domain containing) transforming protein 1 (602 aa)
     
  0.998
GAB1
GRB2-associated binding protein 1 (534 aa)
     
  0.992
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1; Son of sevenless homolog 1 (Drosophila) (1331 aa)
     
  0.992
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2; Son of sevenless homolog 2 (Drosophila) (1241 aa)
     
  0.983
SHC4
SHC adaptor protein 4; SHC (Src homology 2 domain containing) family, member 4 (617 aa)
     
  0.979
IRS1
Insulin receptor substrate 1 (1076 aa)
       
  0.977
ERBB2
Receptor protein-tyrosine kinase; V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (1250 aa)
       
  0.975
GAB2
GRB2-associated binding protein 2 (550 aa)
       
 
  0.975
SHC3
SHC adaptor protein 3; SHC (Src homology 2 domain containing) transforming protein 3 (630 aa)
     
0.962
SHC2
SHC (Src homology 2 domain containing) transforming protein 2 (633 aa)
     
0.961
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, Latimeria chalumnae, coelacanth
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