Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SHPRHSNF2 histone linker PHD RING helicase. (1577 aa)    
Predicted Functional Partners:
RAD18
RAD18 E3 ubiquitin protein ligase.
    
 0.990
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.983
UBE2V2
Ubiquitin conjugating enzyme E2 V2.
    
 0.888
UBE2N
Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.840
H4C11
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.810
HLTF
Helicase like transcription factor.
   
 
0.809
ERCC6
ERCC excision repair 6, chromatin remodeling factor.
  
  
 0.805
MYSM1
Myb like, SWIRM and MPN domains 1.
   
 0.731
H2ZWI5_LATCH
Uncharacterized protein.
  
 
 0.707
FANCM
FA complementation group M.
   
 0.704
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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