KLHL15 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

KLHL15

Kelch like family member 15. (249 aa)

Predicted Functional Partners:

CUL3

0.980

ZNF511

0.758

RBBP8

0.748

CUL1

0.701

ELP5

0.701

SMIM12

0.683

APOO

0.672

APPBP2

0.667

CCDC89

0.641

COPS5

0.633

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOO	KLHL15	ENSLACP00000005474	ENSLACP00000001055	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	Kelch like family member 15.	0.672
APPBP2	CCDC89	ENSLACP00000019150	ENSLACP00000022364	Amyloid beta precursor protein binding protein 2.	Zgc:172182.	0.699
APPBP2	KLHL15	ENSLACP00000019150	ENSLACP00000001055	Amyloid beta precursor protein binding protein 2.	Kelch like family member 15.	0.667
CCDC89	APPBP2	ENSLACP00000022364	ENSLACP00000019150	Zgc:172182.	Amyloid beta precursor protein binding protein 2.	0.699
CCDC89	KLHL15	ENSLACP00000022364	ENSLACP00000001055	Zgc:172182.	Kelch like family member 15.	0.641
CCDC89	ZNF511	ENSLACP00000022364	ENSLACP00000014439	Zgc:172182.	Zinc finger protein 511.	0.470
COPS5	CUL1	ENSLACP00000002782	ENSLACP00000003516	COP9 signalosome subunit 5.	Cullin 1; Belongs to the cullin family.	0.996
COPS5	CUL3	ENSLACP00000002782	ENSLACP00000019775	COP9 signalosome subunit 5.	Cullin 3; Belongs to the cullin family.	0.995
COPS5	KLHL15	ENSLACP00000002782	ENSLACP00000001055	COP9 signalosome subunit 5.	Kelch like family member 15.	0.633
CUL1	COPS5	ENSLACP00000003516	ENSLACP00000002782	Cullin 1; Belongs to the cullin family.	COP9 signalosome subunit 5.	0.996
CUL1	CUL3	ENSLACP00000003516	ENSLACP00000019775	Cullin 1; Belongs to the cullin family.	Cullin 3; Belongs to the cullin family.	0.968
CUL1	KLHL15	ENSLACP00000003516	ENSLACP00000001055	Cullin 1; Belongs to the cullin family.	Kelch like family member 15.	0.701
CUL3	COPS5	ENSLACP00000019775	ENSLACP00000002782	Cullin 3; Belongs to the cullin family.	COP9 signalosome subunit 5.	0.995
CUL3	CUL1	ENSLACP00000019775	ENSLACP00000003516	Cullin 3; Belongs to the cullin family.	Cullin 1; Belongs to the cullin family.	0.968
CUL3	KLHL15	ENSLACP00000019775	ENSLACP00000001055	Cullin 3; Belongs to the cullin family.	Kelch like family member 15.	0.980
ELP5	KLHL15	ENSLACP00000009403	ENSLACP00000001055	Uncharacterized protein.	Kelch like family member 15.	0.701
KLHL15	APOO	ENSLACP00000001055	ENSLACP00000005474	Kelch like family member 15.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.672
KLHL15	APPBP2	ENSLACP00000001055	ENSLACP00000019150	Kelch like family member 15.	Amyloid beta precursor protein binding protein 2.	0.667
KLHL15	CCDC89	ENSLACP00000001055	ENSLACP00000022364	Kelch like family member 15.	Zgc:172182.	0.641
KLHL15	COPS5	ENSLACP00000001055	ENSLACP00000002782	Kelch like family member 15.	COP9 signalosome subunit 5.	0.633