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PIF1 protein (Latimeria chalumnae) - STRING interaction network
PIF1 5'-to-3' DNA helicase in Latimeria chalumnae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIF1PIF1 5’-to-3’ DNA helicase; Belongs to the helicase family (630 aa)    
Predicted Functional Partners:
TIMELESS
Timeless circadian clock (1272 aa)
     
 
  0.923
DNA2
DNA replication helicase/nuclease 2 (925 aa)
   
 
  0.915
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (260 aa)
   
 
  0.897
RAD52
RAD52 homolog, DNA repair protein; RAD52 homolog (S. cerevisiae) (389 aa)
     
 
  0.877
RAD51
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (341 aa)
   
 
  0.872
BLM
Bloom syndrome, RecQ helicase-like (1450 aa)
   
 
  0.864
WRN
Werner syndrome, RecQ helicase-like (1469 aa)
   
 
  0.853
POLA1
Uncharacterized protein; Polymerase (DNA directed), alpha 1 (630 aa)
     
 
  0.824
FBXO18
F-box protein, helicase, 18 (795 aa)
   
 
  0.815
ATR
ATR serine/threonine kinase (2654 aa)
   
 
  0.815
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, Latimeria chalumnae, coelacanth
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