Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ERBB4Protein kinase domain-containing protein. (479 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
    
 0.912
ERBB4-2
Protein kinase domain-containing protein.
 
      0.900
NRG2
Neuregulin 2.
    
 0.828
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.827
ITSN2
Intersectin 2.
    
 0.814
GAB1
GRB2 associated binding protein 1.
    
 0.793
RNF41
Ring finger protein 41.
    
 0.791
HBEGF
Heparin binding EGF like growth factor.
    
 0.781
CBLB
Cbl proto-oncogene B.
    
 0.777
H3AWW7_LATCH
Uncharacterized protein.
    
 0.777
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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