STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERBB4Protein kinase domain-containing protein. (479 aa)    
Predicted Functional Partners:
ERBB4-2
Protein kinase domain-containing protein.
 
      0.900
GRB2
Growth factor receptor bound protein 2.
    
 0.876
MET
MET proto-oncogene, receptor tyrosine kinase.
   
0.801
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.768
SHC3
SHC adaptor protein 3.
    
 0.754
SHC1
SHC adaptor protein 1.
    
 0.754
CBLB
Cbl proto-oncogene B.
    
 0.750
H3AWW7_LATCH
Uncharacterized protein.
    
 0.750
CBL
Cbl proto-oncogene.
    
 0.750
GRAP2
GRB2 related adaptor protein 2.
    
 0.741
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.