STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H3F3BHistone H3; Belongs to the histone H3 family. (136 aa)    
Predicted Functional Partners:
H4C11
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 
 0.991
KDM6B
Lysine demethylase 6B.
   
 0.887
H3A5E7_LATCH
Histone H2B; Belongs to the histone H2B family.
 
 
 0.875
H2ZS39_LATCH
Histone H2B; Belongs to the histone H2B family.
 
 
 0.867
KDM6A
Lysine (K)-specific demethylase 6A.
   
 0.867
H3A427_LATCH
Histone H2B; Belongs to the histone H2B family.
 
 
 0.866
H3A2S8_LATCH
Histone H2B; Belongs to the histone H2B family.
 
 
 0.865
H2ZZP4_LATCH
Histone H2B; Belongs to the histone H2B family.
 
 
 0.864
LOC102361505
Histone H2B; Belongs to the histone H2B family.
 
 
 0.864
H2BE1
Histone H2B; Belongs to the histone H2B family.
 
 
 0.849
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.