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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPROProtein tyrosine phosphatase receptor type O. (1222 aa)    
Predicted Functional Partners:
MET
MET proto-oncogene, receptor tyrosine kinase.
    
 0.970
SCAI
Suppressor of cancer cell invasion.
      
 0.814
PDGFRA
Uncharacterized protein.
   
 0.536
SLITRK2
SLIT and NTRK like family member 2.
    
 0.524
RPL13A
Ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family.
   
  0.513
LOC102363060
Tyrosine-protein kinase receptor.
    
 0.442
ALK
ALK receptor tyrosine kinase.
    
 0.442
ROS1
Tyrosine-protein kinase receptor.
    
  0.434
CHD1L
Chromodomain helicase DNA binding protein 1 like.
    
 
 0.427
TBC1D31
TBC1 domain family member 31.
      
 0.418
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.