LOC102346521 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

LOC102346521

Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (319 aa)

Predicted Functional Partners:

PEX19

0.708

PEX12

0.621

PEX13

0.602

PEX16

0.598

PEX3

0.570

PXMP4

0.524

LOC102360643

0.469

MPV17L2

0.462

PXMP2

0.462

PEX11G

0.456

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102346521	LOC102360643	ENSLACP00000001183	ENSLACP00000021856	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family.	0.469
LOC102346521	MPV17L2	ENSLACP00000001183	ENSLACP00000015189	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.462
LOC102346521	PEX11G	ENSLACP00000001183	ENSLACP00000003324	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Peroxisomal biogenesis factor 11 gamma.	0.456
LOC102346521	PEX12	ENSLACP00000001183	ENSLACP00000019682	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.621
LOC102346521	PEX13	ENSLACP00000001183	ENSLACP00000007915	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	SH3 domain-containing protein.	0.602
LOC102346521	PEX16	ENSLACP00000001183	ENSLACP00000021091	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Peroxisomal membrane protein PEX16.	0.598
LOC102346521	PEX19	ENSLACP00000001183	ENSLACP00000009646	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Peroxisomal biogenesis factor 19.	0.708
LOC102346521	PEX3	ENSLACP00000001183	ENSLACP00000001807	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Peroxisomal biogenesis factor 3.	0.570
LOC102346521	PXMP2	ENSLACP00000001183	ENSLACP00000023375	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Peroxisomal membrane protein 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.462
LOC102346521	PXMP4	ENSLACP00000001183	ENSLACP00000007566	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Peroxisomal membrane protein 4; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.524
LOC102360643	LOC102346521	ENSLACP00000021856	ENSLACP00000001183	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family.	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.469
MPV17L2	LOC102346521	ENSLACP00000015189	ENSLACP00000001183	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.462
MPV17L2	PEX11G	ENSLACP00000015189	ENSLACP00000003324	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisomal biogenesis factor 11 gamma.	0.516
MPV17L2	PEX12	ENSLACP00000015189	ENSLACP00000019682	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.665
MPV17L2	PEX13	ENSLACP00000015189	ENSLACP00000007915	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	SH3 domain-containing protein.	0.693
MPV17L2	PEX16	ENSLACP00000015189	ENSLACP00000021091	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisomal membrane protein PEX16.	0.736
MPV17L2	PEX19	ENSLACP00000015189	ENSLACP00000009646	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisomal biogenesis factor 19.	0.781
MPV17L2	PEX3	ENSLACP00000015189	ENSLACP00000001807	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisomal biogenesis factor 3.	0.639
MPV17L2	PXMP4	ENSLACP00000015189	ENSLACP00000007566	MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.	Peroxisomal membrane protein 4; Belongs to the peroxisomal membrane protein PXMP2/4 family.	0.603
PEX11G	LOC102346521	ENSLACP00000003324	ENSLACP00000001183	Peroxisomal biogenesis factor 11 gamma.	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.456

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.739

expected number of edges:

12

PPI enrichment p-value:

8.67e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008360

Regulation of cell shape

6 of 118

1.96

2.95

2.83e-07

GO:0007163

Establishment or maintenance of cell polarity

6 of 162

1.82

2.59

8.96e-07

GO:0030865

Cortical cytoskeleton organization

4 of 51

2.14

2.36

1.99e-05

GO:0032956

Regulation of actin cytoskeleton organization

6 of 286

1.57

1.96

8.33e-06

GO:0030036

Actin cytoskeleton organization

7 of 487

1.41

1.76

5.20e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

4 of 287

1.39

0.64

0.0437

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043296

Apical junction complex

4 of 115

1.79

1.52

0.00064

GO:0005911

Cell-cell junction

5 of 376

1.37

1.2

0.00088

GO:0005938

Cell cortex

4 of 238

1.48

1.08

0.0036

GO:0005923

Bicellular tight junction

3 of 96

1.74

1.05

0.0078

GO:0005856

Cytoskeleton

7 of 1958

0.8

0.56

0.0078

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14053

Mixed, incl. Small GTPase Rho, and RHOU GTPase cycle

3 of 65

1.91

0.81

0.0285

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fca04530

Tight junction

7 of 146

1.93

3.97

1.66e-10

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2173791

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

3 of 15

2.55

2.02

0.00018

MAP-416572

Sema4D induced cell migration and growth-cone collapse

2 of 9

2.6

1.31

0.0040

MAP-400685

Sema4D in semaphorin signaling

2 of 12

2.47

1.26

0.0049

MAP-9012999

RHO GTPase cycle

6 of 577

1.27

1.23

0.00024

MAP-416482

G alpha (12/13) signalling events

3 of 85

1.8

1.19

0.0040

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070161

Anchoring junction

5 of 306

1.46

1.29

0.00077

GOCC:0070160

Tight junction

3 of 56

1.98

1.24

0.0039

GOCC:0005911

Cell-cell junction

4 of 219

1.51

1.08

0.0039

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

4 of 170

1.62

1.41

0.00073

KW-0547

Nucleotide-binding

5 of 961

0.97

0.59

0.0200

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003578

Small GTPase Rho

4 of 22

2.51

2.78

5.67e-06

IPR001806

Small GTPase

4 of 130

1.74

1.26

0.0024

IPR005225

Small GTP-binding protein domain

4 of 151

1.67

1.21

0.0028

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

4 of 20

2.55

3.34

4.66e-07

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