STRINGSTRING
LTK protein (Latimeria chalumnae) - STRING interaction network
"LTK" - Leukocyte receptor tyrosine kinase in Latimeria chalumnae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LTKLeukocyte receptor tyrosine kinase (1012 aa)    
Predicted Functional Partners:
GAB1
GRB2-associated binding protein 1 (534 aa)
     
  0.698
KRAS
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (189 aa)
       
  0.582
NRAS
Neuroblastoma RAS viral (v-ras) oncogene homolog (189 aa)
       
  0.582
HRAS
Harvey rat sarcoma viral oncogene homolog (193 aa)
       
  0.582
GRB2
Growth factor receptor-bound protein 2 (292 aa)
       
  0.582
GRAP
Uncharacterized protein (99 aa)
       
  0.577
GRAP2
GRB2-related adaptor protein 2 (309 aa)
       
  0.577
ERBB4
V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (789 aa)
     
 
  0.577
HGF
Hepatocyte growth factor (hepapoietin A; scatter factor); Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (720 aa)
       
  0.572
PLG
Plasminogen (725 aa)
       
  0.572
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: Actinistia, Choanichthyes, Coelacanthidae, Coelacanthiformes, Coelacanthimorpha, Crossopterygii, L. chalumnae, Latimeria, Latimeria chalumnae, Latimeriidae, coelacanth, coelacanths, lobe-finned fishes
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