STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SKA1Spindle and kinetochore associated complex subunit 1. (255 aa)    
Predicted Functional Partners:
SKA3
Spindle and kinetochore associated complex subunit 3.
   
 
 0.977
SKA2
Spindle and kinetochore associated complex subunit 2.
   
 
 0.971
KIF11
Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
  
 0.902
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
   
 
 0.863
H3A0V9_LATCH
DUF5595 domain-containing protein.
   
 
 0.852
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 
 0.851
ESPL1
Extra spindle pole bodies like 1, separase.
   
 
 0.833
RTEL1
Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]
   
  
 0.821
PLK1
Serine/threonine-protein kinase PLK.
   
 
 0.803
CDC20
Cell division cycle 20.
   
 
 0.791
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.