NTHL1 protein (Latimeria chalumnae) - STRING interaction network

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NTHL1

Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (350 aa)

Predicted Functional Partners:

APEX1

0.995

NEIL1

0.925

LOC102359858

0.923

APEX2

0.905

ERCC4

0.859

MLH1

0.839

H3AC16_LATCH

0.801

MTHFD1

0.770

H3ATF3_LATCH

0.762

FANCM

0.754

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEX1	ERCC4	ENSLACP00000009774	ENSLACP00000007162	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	ERCC excision repair 4, endonuclease catalytic subunit.	0.869
APEX1	H3AC16_LATCH	ENSLACP00000009774	ENSLACP00000007187	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.951
APEX1	LOC102359858	ENSLACP00000009774	ENSLACP00000023000	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Si:ch211-141o9.10.	0.989
APEX1	NEIL1	ENSLACP00000009774	ENSLACP00000019054	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Nei like DNA glycosylase 1.	0.600
APEX1	NTHL1	ENSLACP00000009774	ENSLACP00000001243	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.995
APEX2	ERCC4	ENSLACP00000000968	ENSLACP00000007162	Apurinic/apyrimidinic endodeoxyribonuclease 2.	ERCC excision repair 4, endonuclease catalytic subunit.	0.851
APEX2	H3AC16_LATCH	ENSLACP00000000968	ENSLACP00000007187	Apurinic/apyrimidinic endodeoxyribonuclease 2.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.414
APEX2	LOC102359858	ENSLACP00000000968	ENSLACP00000023000	Apurinic/apyrimidinic endodeoxyribonuclease 2.	Si:ch211-141o9.10.	0.847
APEX2	NTHL1	ENSLACP00000000968	ENSLACP00000001243	Apurinic/apyrimidinic endodeoxyribonuclease 2.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.905
ERCC4	APEX1	ENSLACP00000007162	ENSLACP00000009774	ERCC excision repair 4, endonuclease catalytic subunit.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.869
ERCC4	APEX2	ENSLACP00000007162	ENSLACP00000000968	ERCC excision repair 4, endonuclease catalytic subunit.	Apurinic/apyrimidinic endodeoxyribonuclease 2.	0.851
ERCC4	FANCM	ENSLACP00000007162	ENSLACP00000008755	ERCC excision repair 4, endonuclease catalytic subunit.	FA complementation group M.	0.887
ERCC4	H3AC16_LATCH	ENSLACP00000007162	ENSLACP00000007187	ERCC excision repair 4, endonuclease catalytic subunit.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.607
ERCC4	LOC102359858	ENSLACP00000007162	ENSLACP00000023000	ERCC excision repair 4, endonuclease catalytic subunit.	Si:ch211-141o9.10.	0.938
ERCC4	MLH1	ENSLACP00000007162	ENSLACP00000008921	ERCC excision repair 4, endonuclease catalytic subunit.	MutL homolog 1.	0.624
ERCC4	NTHL1	ENSLACP00000007162	ENSLACP00000001243	ERCC excision repair 4, endonuclease catalytic subunit.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.859
FANCM	ERCC4	ENSLACP00000008755	ENSLACP00000007162	FA complementation group M.	ERCC excision repair 4, endonuclease catalytic subunit.	0.887
FANCM	H3AC16_LATCH	ENSLACP00000008755	ENSLACP00000007187	FA complementation group M.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.404
FANCM	LOC102359858	ENSLACP00000008755	ENSLACP00000023000	FA complementation group M.	Si:ch211-141o9.10.	0.958
FANCM	MLH1	ENSLACP00000008755	ENSLACP00000008921	FA complementation group M.	MutL homolog 1.	0.680

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