Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H2ZV40_LATCHProtein kinase domain-containing protein. (266 aa)    
Predicted Functional Partners:
RIPK1
Receptor interacting serine/threonine kinase 1.
    
 0.999
FADD
Fas associated via death domain.
   
 0.994
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.976
CASP10
Caspase 10; Belongs to the peptidase C14A family.
   
 0.939
H3A2R2_LATCH
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.939
H3A526_LATCH
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.939
PELI1
Pellino E3 ubiquitin protein ligase 1.
    
 0.890
TRADD
Death domain-containing protein.
    
 0.804
STUB1
STIP1 homology and U-box containing protein 1.
    
 0.759
LOC102356355
TNFR-Cys domain-containing protein.
   
 0.720
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: medium (48%) [HD]