STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIRAS1DIRAS family GTPase 1. (198 aa)    
Predicted Functional Partners:
ITSN2
Intersectin 2.
    
 0.844
PIK3CB
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.
    
 0.810
H3AJ45_LATCH
Uncharacterized protein.
    
 0.734
ITSN1
Intersectin 1 (SH3 domain protein).
    
 0.734
LOC102351219
Rap guanine nucleotide exchange factor (GEF) 3.
    
 0.642
RAPGEF4
Rap guanine nucleotide exchange factor 4.
    
 0.642
NF1
Neurofibromin 1.
    
 0.641
MET
MET proto-oncogene, receptor tyrosine kinase.
   
 0.624
RASGRP3
RAS guanyl releasing protein 3.
    
 0.614
RASGRP1
RAS guanyl releasing protein 1.
    
 0.614
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.