| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AADAT | AFMID | ENSLACP00000003451 | ENSLACP00000020091 | Aminoadipate aminotransferase. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.937 |
| AADAT | HAAO | ENSLACP00000003451 | ENSLACP00000001313 | Aminoadipate aminotransferase. | Uncharacterized protein. | 0.584 |
| AADAT | KMO | ENSLACP00000003451 | ENSLACP00000009168 | Aminoadipate aminotransferase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.959 |
| AADAT | KYNU | ENSLACP00000003451 | ENSLACP00000023152 | Aminoadipate aminotransferase. | Kynureninase. | 0.956 |
| AADAT | QPRT | ENSLACP00000003451 | ENSLACP00000002514 | Aminoadipate aminotransferase. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.471 |
| AFMID | AADAT | ENSLACP00000020091 | ENSLACP00000003451 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Aminoadipate aminotransferase. | 0.937 |
| AFMID | H3A8S5_LATCH | ENSLACP00000020091 | ENSLACP00000006046 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Nicotinate phosphoribosyltransferase. | 0.602 |
| AFMID | HAAO | ENSLACP00000020091 | ENSLACP00000001313 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Uncharacterized protein. | 0.616 |
| AFMID | IDO2 | ENSLACP00000020091 | ENSLACP00000003333 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Indoleamine 2,3-dioxygenase 1. | 0.950 |
| AFMID | KMO | ENSLACP00000020091 | ENSLACP00000009168 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.975 |
| AFMID | KYNU | ENSLACP00000020091 | ENSLACP00000023152 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynureninase. | 0.977 |
| AFMID | NADSYN1 | ENSLACP00000020091 | ENSLACP00000017676 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.576 |
| AFMID | QPRT | ENSLACP00000020091 | ENSLACP00000002514 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.556 |
| AFMID | TDO2 | ENSLACP00000020091 | ENSLACP00000000384 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Tryptophan 2,3-dioxygenase. | 0.982 |
| CAT | HAAO | ENSLACP00000008889 | ENSLACP00000001313 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. | Uncharacterized protein. | 0.911 |
| CAT | KYNU | ENSLACP00000008889 | ENSLACP00000023152 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. | Kynureninase. | 0.914 |
| H3A8S5_LATCH | AFMID | ENSLACP00000006046 | ENSLACP00000020091 | Nicotinate phosphoribosyltransferase. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.602 |
| H3A8S5_LATCH | HAAO | ENSLACP00000006046 | ENSLACP00000001313 | Nicotinate phosphoribosyltransferase. | Uncharacterized protein. | 0.722 |
| H3A8S5_LATCH | IDO2 | ENSLACP00000006046 | ENSLACP00000003333 | Nicotinate phosphoribosyltransferase. | Indoleamine 2,3-dioxygenase 1. | 0.659 |
| H3A8S5_LATCH | KMO | ENSLACP00000006046 | ENSLACP00000009168 | Nicotinate phosphoribosyltransferase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.707 |