Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SIN3BSIN3 transcription regulator family member B. (1150 aa)    
Predicted Functional Partners:
ARID4A
AT-rich interaction domain 4A.
   
 0.963
PHF12
PHD finger protein 12.
   
 0.951
MECP2
Methyl-CpG binding protein 2.
    
 0.949
SAP130
Sin3A associated protein 130.
   
 0.941
SUDS3
SDS3 homolog, SIN3A corepressor complex component.
   
 0.926
SINHCAF
SIN3-HDAC complex associated factor.
    
 0.906
HDAC3
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
   
 0.899
HDAC8
Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
   
 0.898
HDAC1
Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
   
 0.898
NCOR1
Nuclear receptor corepressor 1.
   
 0.895
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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