Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ITGB8Integrin beta; Belongs to the integrin beta chain family. (637 aa)    
Predicted Functional Partners:
ITGAV
Integrin_alpha2 domain-containing protein.
    
 0.999
VTN
Vitronectin b.
    
 0.972
ITGA8
Integrin subunit alpha 8; Belongs to the integrin alpha chain family.
    
 0.965
PXN
Paxillin.
    
 0.946
TLN2
Talin 2.
   
 0.942
TLN1
Talin 1.
   
 0.938
TGFB1
Transforming growth factor beta; Belongs to the TGF-beta family.
   
 0.934
TGFB3
Transforming growth factor beta; Belongs to the TGF-beta family.
   
 0.929
SRC
Tyrosine-protein kinase.
    
 0.924
FN1
Fibronectin 1.
   
 
 0.917
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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