STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (664 aa)    
Predicted Functional Partners:
MAP2K5
Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.
   
0.931
SMYD3
SET and MYND domain containing 3.
   
 
 0.920
CCM2
CCM2 scaffold protein.
    
 0.790
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.787
MAP2K4
Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.
   
0.768
SRF
Serum response factor.
    
 0.743
SQSTM1
Sequestosome 1.
    
 0.671
CCM2L
CCM2 like scaffold protein.
    
 0.666
MAP2K7
Mitogen-activated protein kinase kinase 7.
    
0.661
MAP2K2
Mitogen-activated protein kinase kinase 2a.
  
0.649
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.