MAP3K2 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

MAP3K2

Mitogen-activated protein kinase kinase kinase 2. (664 aa)

Predicted Functional Partners:

MAP2K5

0.996

SMYD3

0.965

MAP3K3

0.955

LOC102350357

0.955

YWHAB

0.953

YWHAZ

0.943

PAK2

0.935

PAK1

0.935

MAP2K4

0.934

MAP2K6

0.918

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102350357	MAP2K4	ENSLACP00000018303	ENSLACP00000023386	Uncharacterized protein.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.705
LOC102350357	MAP2K5	ENSLACP00000018303	ENSLACP00000014381	Uncharacterized protein.	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	0.934
LOC102350357	MAP2K6	ENSLACP00000018303	ENSLACP00000017172	Uncharacterized protein.	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.921
LOC102350357	MAP3K2	ENSLACP00000018303	ENSLACP00000001381	Uncharacterized protein.	Mitogen-activated protein kinase kinase kinase 2.	0.955
LOC102350357	MAP3K3	ENSLACP00000018303	ENSLACP00000014058	Uncharacterized protein.	Mitogen-activated protein kinase kinase kinase 3.	0.901
LOC102350357	PAK1	ENSLACP00000018303	ENSLACP00000008886	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.939
LOC102350357	PAK2	ENSLACP00000018303	ENSLACP00000004711	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.935
LOC102350357	SMYD3	ENSLACP00000018303	ENSLACP00000018131	Uncharacterized protein.	SET and MYND domain containing 3.	0.806
LOC102350357	YWHAB	ENSLACP00000018303	ENSLACP00000007313	Uncharacterized protein.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.	0.799
LOC102350357	YWHAZ	ENSLACP00000018303	ENSLACP00000001531	Uncharacterized protein.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.798
MAP2K4	LOC102350357	ENSLACP00000023386	ENSLACP00000018303	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.705
MAP2K4	MAP3K2	ENSLACP00000023386	ENSLACP00000001381	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 2.	0.934
MAP2K4	MAP3K3	ENSLACP00000023386	ENSLACP00000014058	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 3.	0.705
MAP2K4	YWHAB	ENSLACP00000023386	ENSLACP00000007313	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.	0.589
MAP2K5	LOC102350357	ENSLACP00000014381	ENSLACP00000018303	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.934
MAP2K5	MAP3K2	ENSLACP00000014381	ENSLACP00000001381	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 2.	0.996
MAP2K5	MAP3K3	ENSLACP00000014381	ENSLACP00000014058	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 3.	0.934
MAP2K5	YWHAB	ENSLACP00000014381	ENSLACP00000007313	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.	0.578
MAP2K5	YWHAZ	ENSLACP00000014381	ENSLACP00000001531	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.578
MAP2K6	LOC102350357	ENSLACP00000017172	ENSLACP00000018303	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.921