STRINGSTRING
CDKN2B protein (Latimeria chalumnae) - STRING interaction network
"CDKN2B" - Cyclin-dependent kinase 4 inhibitor B in Latimeria chalumnae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDKN2BCyclin-dependent kinase 4 inhibitor B (128 aa)    
Predicted Functional Partners:
CDK4
Cyclin-dependent kinase 4 (306 aa)
     
  0.964
CDK6
Cyclin-dependent kinase 6 (322 aa)
     
  0.953
CCND1
Cyclin D1 (292 aa)
       
  0.941
ENSLACG00000012491
Uncharacterized protein (327 aa)
     
  0.930
MYC
V-myc myelocytomatosis viral oncogene homolog (avian) (412 aa)
       
  0.924
CCND2
Cyclin D2 (291 aa)
       
  0.892
CCND3
Cyclin D3 (292 aa)
       
  0.892
ENSLACG00000018920
Uncharacterized protein (434 aa)
         
    0.800
TP53
Tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (401 aa)
       
  0.780
UBA52
Uncharacterized protein (128 aa)
     
  0.760
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: Actinistia, Choanichthyes, Coelacanthidae, Coelacanthiformes, Coelacanthimorpha, Crossopterygii, L. chalumnae, Latimeria, Latimeria chalumnae, Latimeriidae, coelacanth, coelacanths, lobe-finned fishes
Server load: low (6%) [HD]