TTC33 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TTC33

Tetratricopeptide repeat domain 33. (159 aa)

Predicted Functional Partners:

LEO1

0.846

GET4

0.836

GET3

0.761

H2ZWQ9_LATCH

0.636

STX5

0.636

RAD23B

0.617

RAD23A

0.617

LOC102353696

0.617

SERP2

0.607

CDC73

0.603

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC73	H2ZWQ9_LATCH	ENSLACP00000001436	ENSLACP00000001830	Cell division cycle 73.	WD_REPEATS_REGION domain-containing protein.	0.828
CDC73	LEO1	ENSLACP00000001436	ENSLACP00000004331	Cell division cycle 73.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.999
CDC73	TTC33	ENSLACP00000001436	ENSLACP00000001422	Cell division cycle 73.	Tetratricopeptide repeat domain 33.	0.603
GET3	GET4	ENSLACP00000010276	ENSLACP00000017371	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Guided entry of tail-anchored proteins factor 4.	0.999
GET3	LOC102353696	ENSLACP00000010276	ENSLACP00000020796	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Uncharacterized protein.	0.832
GET3	RAD23A	ENSLACP00000010276	ENSLACP00000016998	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	RAD23 homolog A, nucleotide excision repair protein.	0.832
GET3	RAD23B	ENSLACP00000010276	ENSLACP00000004049	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	RAD23 homolog B, nucleotide excision repair protein.	0.832
GET3	STX5	ENSLACP00000010276	ENSLACP00000002784	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Syntaxin 5; Belongs to the syntaxin family.	0.837
GET3	TTC33	ENSLACP00000010276	ENSLACP00000001422	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Tetratricopeptide repeat domain 33.	0.761
GET4	GET3	ENSLACP00000017371	ENSLACP00000010276	Guided entry of tail-anchored proteins factor 4.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.999
GET4	LOC102353696	ENSLACP00000017371	ENSLACP00000020796	Guided entry of tail-anchored proteins factor 4.	Uncharacterized protein.	0.721
GET4	RAD23A	ENSLACP00000017371	ENSLACP00000016998	Guided entry of tail-anchored proteins factor 4.	RAD23 homolog A, nucleotide excision repair protein.	0.721
GET4	RAD23B	ENSLACP00000017371	ENSLACP00000004049	Guided entry of tail-anchored proteins factor 4.	RAD23 homolog B, nucleotide excision repair protein.	0.721
GET4	STX5	ENSLACP00000017371	ENSLACP00000002784	Guided entry of tail-anchored proteins factor 4.	Syntaxin 5; Belongs to the syntaxin family.	0.450
GET4	TTC33	ENSLACP00000017371	ENSLACP00000001422	Guided entry of tail-anchored proteins factor 4.	Tetratricopeptide repeat domain 33.	0.836
H2ZWQ9_LATCH	CDC73	ENSLACP00000001830	ENSLACP00000001436	WD_REPEATS_REGION domain-containing protein.	Cell division cycle 73.	0.828
H2ZWQ9_LATCH	LEO1	ENSLACP00000001830	ENSLACP00000004331	WD_REPEATS_REGION domain-containing protein.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.994
H2ZWQ9_LATCH	LOC102353696	ENSLACP00000001830	ENSLACP00000020796	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.758
H2ZWQ9_LATCH	RAD23A	ENSLACP00000001830	ENSLACP00000016998	WD_REPEATS_REGION domain-containing protein.	RAD23 homolog A, nucleotide excision repair protein.	0.758
H2ZWQ9_LATCH	RAD23B	ENSLACP00000001830	ENSLACP00000004049	WD_REPEATS_REGION domain-containing protein.	RAD23 homolog B, nucleotide excision repair protein.	0.758