Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
H2ZVK5_LATCHCytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. (402 aa)    
Predicted Functional Partners:
LOC102345588
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family.
   
 0.968
HSD17B3
Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.961
LOC102360223
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
  
0.951
DHRS11
Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.946
HSD17B2
Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.945
LOC102345423
Uncharacterized protein; Belongs to the cytochrome P450 family.
  
0.944
LOC102365730
Uncharacterized protein; Belongs to the cytochrome P450 family.
  
0.941
HSD11B1
Hydroxysteroid 11-beta dehydrogenase 1.
   
 0.935
CYP19A1
Cytochrome P450 family 19 subfamily A member 1.
  
0.931
LOC102363673
Sulfotransferase; Belongs to the sulfotransferase 1 family.
   
 
 0.927
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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