Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
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[Homology]
Score
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (721 aa)    
Predicted Functional Partners:
NT5E
5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.
   
 
 0.949
NME1
Nucleoside diphosphate kinase.
     
 0.938
NME3
NME/NM23 nucleoside diphosphate kinase 3; Belongs to the NDK family.
     
 0.938
AMPD2
AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
   
 
 0.936
GUCY2C
Guanylate cyclase.
     
 0.934
ENTPD3
Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family.
     
 0.932
PDE7A
Phosphodiesterase.
     
 0.929
TYMS
Thymidylate synthetase.
    
  0.929
AK3
GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
   
 
 0.928
AGL
Amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase.
     
 0.927
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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