Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SQLESE domain-containing protein. (506 aa)    
Predicted Functional Partners:
FDFT1
Farnesyl-diphosphate farnesyltransferase 1.
  
 
 0.993
LSS
Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.
  
 
 0.993
NSDHL
NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.
   
 
 0.933
CYP51A1
Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.
  
 0.931
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
   
 
 0.857
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
  
 0.856
HMGCS1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.852
DHCR7
7-dehydrocholesterol reductase.
   
 
 0.838
IDI1
Isopentenyl-diphosphate delta isomerase 1.
   
  
 0.787
MARCHF6
Membrane associated ring-CH-type finger 6.
    
 
 0.786
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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