Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CGASCyclic GMP-AMP synthase. (370 aa)    
Predicted Functional Partners:
IRF3
Interferon regulatory factor 3.
      
 0.924
STING1
Uncharacterized protein.
    
 0.835
TBK1
TANK binding kinase 1.
      
 0.748
TLR3
Toll like receptor 3; Belongs to the Toll-like receptor family.
      
 0.736
H3B748_LATCH
Interferon regulatory factor 7.
      
 0.711
AIM2
HIN-200 domain-containing protein.
    
 
 0.711
STAT1
Signal transducer and activator of transcription.
      
 0.700
STAT2
Signal transducer and activator of transcription.
      
 0.700
ANKRD17
Ankyrin repeat domain 17.
      
 0.699
DDX41
DEAD-box helicase 41.
      
 0.641
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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