Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PTGS1Prostaglandin-endoperoxide synthase 1. (501 aa)    
Predicted Functional Partners:
PTGS2
Prostaglandin-endoperoxide synthase 2.
  
0.994
TBXAS1
Thromboxane A synthase 1; Belongs to the cytochrome P450 family.
   
 
 0.964
PTGES
Prostaglandin E synthase.
     
 0.957
PTGES2
Prostaglandin E synthase 2; Belongs to the GST superfamily.
     
 0.955
PTGES3
Prostaglandin E synthase 3.
     
 0.947
ALOX5
Arachidonate 5-lipoxygenase.
     
 0.919
PRXL2B
Peroxiredoxin like 2B.
     
 0.913
VIPR1
Vasoactive intestinal peptide receptor 1; Belongs to the G-protein coupled receptor 2 family.
      
 0.910
LOC102357912
Uncharacterized protein.
     
 0.906
LOC102348127
Cytochrome P450, family 2, subfamily U, polypeptide 1.
   
 
 0.905
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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