STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EPS15Epidermal growth factor receptor pathway substrate 15. (455 aa)    
Predicted Functional Partners:
ITSN2
Intersectin 2.
   
0.997
EPN2
Epsin 2.
   
 0.965
AP2A1
Alpha_adaptinC2 domain-containing protein.
   
 0.954
STON2
Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family.
    
 0.946
GAK
J domain-containing protein.
   
 0.942
H3AJ45_LATCH
Uncharacterized protein.
   
0.939
ITSN1
Intersectin 1 (SH3 domain protein).
   
 0.939
FGFR2
Fibroblast growth factor receptor.
    
 0.914
PDGFRA
Uncharacterized protein.
    
 0.914
FGFR4
Fibroblast growth factor receptor.
    
 0.914
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.