STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DHX57DExH-box helicase 57. (1371 aa)    
Predicted Functional Partners:
ITSN2
Intersectin 2.
   
  0.982
AP2M1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
    
 0.791
H3AJ45_LATCH
Uncharacterized protein.
   
  0.774
ITSN1
Intersectin 1 (SH3 domain protein).
   
  0.774
UTP14A
Uncharacterized protein.
   
 0.742
AP2S1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
    
 0.723
NOC4L
Nucleolar complex associated 4 homolog.
   
 0.715
UTP18
UTP18 small subunit processome component.
   
 0.700
SLU7
SLU7 homolog, splicing factor.
    
 0.698
CWC25
CWC25 spliceosome associated protein homolog.
   
 0.690
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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