STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H1-0H1 histone family member 0. (197 aa)    
Predicted Functional Partners:
MACROH2A2
Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.
   
 0.856
H4C11
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.839
KPNB1
Karyopherin subunit beta 1.
    
   0.820
DFFB
DNA fragmentation factor subunit beta.
    
 0.691
H2AZ2
Histone H2A; Belongs to the histone H2A family.
   
 0.661
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.612
H2ZWA0_LATCH
Uncharacterized protein.
    
 0.578
RPA2
Replication protein A2.
    
 0.578
STN1
CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
    
 0.578
SASS6
SAS-6 centriolar assembly protein.
    
 0.578
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.