Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa)    
Predicted Functional Partners:
YWHAB
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.
   
  0.999
CTNNB1
Catenin beta 1.
   
 0.995
TSC2
TSC complex subunit 2.
    
 0.990
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
    
 0.985
CDC25C
Cell division cycle 25C.
    
 0.984
H2ZZQ4_LATCH
LRRCT domain-containing protein.
    
 0.976
MAPT
Microtubule-associated protein.
    
 
 0.976
ARHGEF2
Rho/Rac guanine nucleotide exchange factor 2.
    
 
 0.975
ATXN1
Ataxin 1.
    
 
 0.960
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.958
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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