Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
P2RX5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (363 aa)    
Predicted Functional Partners:
H3B0S1_LATCH
Uncharacterized protein.
      
 0.593
P2RX4
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
     
 0.577
P2RX6
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
    
 0.556
P2RX2
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
    
 0.538
P2RX1
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
    
 0.532
P2RX3
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
     
 0.506
AP2M1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
    
   0.475
P2RY6
Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family.
      
 0.468
MMAB
Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.
      
 0.467
P2RY1
Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family.
      
 0.467
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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