IRAK3 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IRAK3

Interleukin 1 receptor associated kinase 3. (546 aa)

Predicted Functional Partners:

TRAF6

0.844

IRAK4

0.815

MYD88

0.802

IRAK1

0.780

H3AUI4_LATCH

0.758

IKBKE

0.728

TRAF7

0.684

TOLLIP

0.665

LOC102361424

0.598

IL1RAP

0.560

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3AUI4_LATCH	IL1RAP	ENSLACP00000013305	ENSLACP00000018442	Uncharacterized protein.	Interleukin 1 receptor accessory protein.	0.691
H3AUI4_LATCH	IRAK1	ENSLACP00000013305	ENSLACP00000014884	Uncharacterized protein.	Interleukin 1 receptor associated kinase 1.	0.890
H3AUI4_LATCH	IRAK3	ENSLACP00000013305	ENSLACP00000001550	Uncharacterized protein.	Interleukin 1 receptor associated kinase 3.	0.758
H3AUI4_LATCH	IRAK4	ENSLACP00000013305	ENSLACP00000018448	Uncharacterized protein.	Interleukin 1 receptor associated kinase 4.	0.987
H3AUI4_LATCH	MYD88	ENSLACP00000013305	ENSLACP00000019094	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.988
H3AUI4_LATCH	TOLLIP	ENSLACP00000013305	ENSLACP00000023052	Uncharacterized protein.	Toll interacting protein.	0.864
H3AUI4_LATCH	TRAF6	ENSLACP00000013305	ENSLACP00000003556	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.996
IKBKE	IRAK3	ENSLACP00000012245	ENSLACP00000001550	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Interleukin 1 receptor associated kinase 3.	0.728
IKBKE	MYD88	ENSLACP00000012245	ENSLACP00000019094	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.546
IKBKE	TRAF6	ENSLACP00000012245	ENSLACP00000003556	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.902
IKBKE	TRAF7	ENSLACP00000012245	ENSLACP00000009585	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TNF receptor associated factor 7.	0.518
IL1RAP	H3AUI4_LATCH	ENSLACP00000018442	ENSLACP00000013305	Interleukin 1 receptor accessory protein.	Uncharacterized protein.	0.691
IL1RAP	IRAK1	ENSLACP00000018442	ENSLACP00000014884	Interleukin 1 receptor accessory protein.	Interleukin 1 receptor associated kinase 1.	0.789
IL1RAP	IRAK3	ENSLACP00000018442	ENSLACP00000001550	Interleukin 1 receptor accessory protein.	Interleukin 1 receptor associated kinase 3.	0.560
IL1RAP	IRAK4	ENSLACP00000018442	ENSLACP00000018448	Interleukin 1 receptor accessory protein.	Interleukin 1 receptor associated kinase 4.	0.838
IL1RAP	MYD88	ENSLACP00000018442	ENSLACP00000019094	Interleukin 1 receptor accessory protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.835
IL1RAP	TOLLIP	ENSLACP00000018442	ENSLACP00000023052	Interleukin 1 receptor accessory protein.	Toll interacting protein.	0.766
IL1RAP	TRAF6	ENSLACP00000018442	ENSLACP00000003556	Interleukin 1 receptor accessory protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.824
IRAK1	H3AUI4_LATCH	ENSLACP00000014884	ENSLACP00000013305	Interleukin 1 receptor associated kinase 1.	Uncharacterized protein.	0.890
IRAK1	IL1RAP	ENSLACP00000014884	ENSLACP00000018442	Interleukin 1 receptor associated kinase 1.	Interleukin 1 receptor accessory protein.	0.789