Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
IRAK3Interleukin 1 receptor associated kinase 3. (546 aa)    
Predicted Functional Partners:
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.927
IRAK4
Interleukin 1 receptor associated kinase 4.
    
 0.869
H3AUI4_LATCH
Uncharacterized protein.
    
 0.858
IRAK1
Interleukin 1 receptor associated kinase 1.
    
 0.858
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
    
 0.763
IKBKE
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
    
 0.710
TRAF7
TNF receptor associated factor 7.
   
 0.684
LEMD3
LEM domain containing 3.
    
 0.636
SUSD2
Sushi domain containing 2.
      
 0.635
TOLLIP
Toll interacting protein.
    
 0.626
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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