Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHG1Pleckstrin homology and RhoGEF domain containing G1. (1193 aa)    
Predicted Functional Partners:
IYD
Iodotyrosine deiodinase.
      
 0.781
CDC42
Cell division cycle 42.
    
 0.742
MPPED2
Metallophosphoesterase domain containing 2.
      
 0.723
LOC102362077
Ras homolog gene family, member Gc.
    
 0.686
RHOG
Ras homolog family member G.
    
 0.686
LOC102352539
Uncharacterized protein.
     
  0.678
TNS4
Tensin 4.
      
 0.670
PSD2
Pleckstrin and Sec7 domain containing 2.
      
 0.652
ZMAT4
Zinc finger matrin-type 4.
      
 0.651
DYNC1LI2
Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
      
 0.646
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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