STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APPAmyloid beta precursor protein. (652 aa)    
Predicted Functional Partners:
SORL1
Sortilin-related receptor, L(DLR class) A repeats containing.
    
 0.973
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 
 0.971
APBA2
Amyloid beta precursor protein binding family A member 2.
   
 
 0.964
APBA1
Amyloid beta precursor protein binding family A member 1.
   
 
 0.955
NCSTN
Nicastrin.
    
 0.952
IDE
Insulin degrading enzyme; Belongs to the peptidase M16 family.
    
 
 0.943
TNFRSF21
TNF receptor superfamily member 21.
    
 
 0.943
LOC102345227
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
 
  
 0.936
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 
 0.925
PITRM1
Pitrilysin metallopeptidase 1.
    
 
 0.901
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.