STRINGSTRING
APP protein (Latimeria chalumnae) - STRING interaction network
"APP" - Amyloid beta in Latimeria chalumnae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APPAmyloid beta (A4) precursor protein (652 aa)    
Predicted Functional Partners:
APBB2
Amyloid beta (A4) precursor protein-binding, family B, member 2 (745 aa)
       
 
  0.936
APBB3
Amyloid beta (A4) precursor protein-binding, family B, member 3 (260 aa)
       
 
  0.936
APLP2
Amyloid beta (A4) precursor-like protein 2 (732 aa)
     
 
0.813
APLP1
Amyloid beta (A4) precursor-like protein 1 (699 aa)
     
 
0.796
APBA1
Amyloid beta (A4) precursor protein-binding, family A, member 1 (812 aa)
     
 
  0.749
APBA2
Amyloid beta (A4) precursor protein-binding, family A, member 2 (757 aa)
     
 
  0.749
APBA3
Amyloid beta (A4) precursor protein-binding, family A, member 3 (462 aa)
     
 
  0.749
PSEN2
Presenilin 2 (Alzheimer disease 4); Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (458 aa)
       
  0.685
PSEN1
Presenilin 1; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (465 aa)
       
  0.685
SORL1
Sortilin-related receptor, L(DLR class) A repeats containing (1410 aa)
     
  0.677
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: Actinistia, Choanichthyes, Coelacanthidae, Coelacanthiformes, Coelacanthimorpha, Crossopterygii, L. chalumnae, Latimeria, Latimeria chalumnae, Latimeriidae, coelacanth, coelacanths, lobe-finned fishes
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