EN2 protein (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

EN2

Homeobox protein engrailed-like. (262 aa)

Predicted Functional Partners:

FGF8

0.666

HOXD10

0.619

WNT1

0.589

EN1

0.567

PAX2

0.528

NOL9

0.526

PAX8

0.500

H3A2B0_LATCH

0.468

VPS45

0.467

LMBR1

0.454

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EN1	EN2	ENSLACP00000019687	ENSLACP00000001649	Homeobox protein engrailed-like.	Homeobox protein engrailed-like.	0.567
EN1	FGF8	ENSLACP00000019687	ENSLACP00000007843	Homeobox protein engrailed-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.719
EN1	NOL9	ENSLACP00000019687	ENSLACP00000019005	Homeobox protein engrailed-like.	Nucleolar protein 9.	0.428
EN1	PAX2	ENSLACP00000019687	ENSLACP00000019870	Homeobox protein engrailed-like.	Paired box 2.	0.554
EN1	PAX8	ENSLACP00000019687	ENSLACP00000004228	Homeobox protein engrailed-like.	Paired box 8.	0.706
EN1	WNT1	ENSLACP00000019687	ENSLACP00000021628	Homeobox protein engrailed-like.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.718
EN2	EN1	ENSLACP00000001649	ENSLACP00000019687	Homeobox protein engrailed-like.	Homeobox protein engrailed-like.	0.567
EN2	FGF8	ENSLACP00000001649	ENSLACP00000007843	Homeobox protein engrailed-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.666
EN2	H3A2B0_LATCH	ENSLACP00000001649	ENSLACP00000003781	Homeobox protein engrailed-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.468
EN2	HOXD10	ENSLACP00000001649	ENSLACP00000010708	Homeobox protein engrailed-like.	Homeobox D10.	0.619
EN2	LMBR1	ENSLACP00000001649	ENSLACP00000010111	Homeobox protein engrailed-like.	Limb development membrane protein 1; Belongs to the LIMR family.	0.454
EN2	NOL9	ENSLACP00000001649	ENSLACP00000019005	Homeobox protein engrailed-like.	Nucleolar protein 9.	0.526
EN2	PAX2	ENSLACP00000001649	ENSLACP00000019870	Homeobox protein engrailed-like.	Paired box 2.	0.528
EN2	PAX8	ENSLACP00000001649	ENSLACP00000004228	Homeobox protein engrailed-like.	Paired box 8.	0.500
EN2	VPS45	ENSLACP00000001649	ENSLACP00000015021	Homeobox protein engrailed-like.	Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family.	0.467
EN2	WNT1	ENSLACP00000001649	ENSLACP00000021628	Homeobox protein engrailed-like.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.589
FGF8	EN1	ENSLACP00000007843	ENSLACP00000019687	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein engrailed-like.	0.719
FGF8	EN2	ENSLACP00000007843	ENSLACP00000001649	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein engrailed-like.	0.666
FGF8	PAX2	ENSLACP00000007843	ENSLACP00000019870	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Paired box 2.	0.561
FGF8	WNT1	ENSLACP00000007843	ENSLACP00000021628	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.792