Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HSCBHscB mitochondrial iron-sulfur cluster cochaperone. (257 aa)    
Predicted Functional Partners:
HSPA9
Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family.
   
 0.986
ISCU
Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
  
 0.889
ISCA2
Iron-sulfur cluster assembly 2.
   
 
 0.817
NFS1
NFS1 cysteine desulfurase.
  
 
 0.769
GLRX5
Glutaredoxin 5.
    
 0.752
HSPD1
Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family.
  
 0.736
LYRM7
LYR motif containing 7; Belongs to the complex I LYR family.
    
 0.682
ISCA1
Iron-sulfur cluster assembly 1.
     
 0.675
NDUFV2
NADH:ubiquinone oxidoreductase core subunit V2.
   
  0.670
UQCRFS1
Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
    
 0.661
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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