Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MAPK6Mitogen-activated protein kinase 6. (721 aa)    
Predicted Functional Partners:
MAPKAPK5
MAPK activated protein kinase 5.
    
 0.998
MAPK4
Mitogen-activated protein kinase 4.
   
 
  0.993
H3B606_LATCH
Neuralized E3 ubiquitin protein ligase 4.
    
 
 0.958
PAK2
Non-specific serine/threonine protein kinase.
   
 0.942
XPO1
Exportin 1.
    
 0.942
CDC14A
Uncharacterized protein.
    
 0.818
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.807
CDC14B
Cell division cycle 14B.
    
 0.776
CDC42
Cell division cycle 42.
   
 0.758
TRIO
Trio Rho guanine nucleotide exchange factor.
   
 0.741
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.