STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IRF1Interferon regulatory factor. (264 aa)    
Predicted Functional Partners:
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.858
STAT1
Signal transducer and activator of transcription.
   
 0.825
STAT2
Signal transducer and activator of transcription.
   
 0.824
LOC102352539
Uncharacterized protein.
    
 0.805
TLR3
Toll like receptor 3; Belongs to the Toll-like receptor family.
   
 
 0.748
STAT3
Signal transducer and activator of transcription.
   
 0.748
IRF2
Interferon regulatory factor.
  
0.697
H3A316_LATCH
IRF tryptophan pentad repeat domain-containing protein.
  
0.669
SOCS1
Suppressor of cytokine signaling 1a.
   
 
 0.663
PSMB9
Proteasome subunit beta.
   
  
 0.651
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.