Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (156 aa)    
Predicted Functional Partners:
AP1G1
AP-1 complex subunit gamma.
    
 0.986
AP1G2
AP-1 complex subunit gamma.
    
 0.986
AP1B1
AP complex subunit beta.
   
 0.981
AP1M1
AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
   
 0.978
H3A0Z7_LATCH
Adaptor related protein complex 1 subunit mu 3; Belongs to the adaptor complexes medium subunit family.
   
 0.978
AP1M2
AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
   
 0.978
AP1S1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
  
  
 
0.902
AP1S2
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
  
  
 
0.901
AP2B1
AP complex subunit beta.
   
 0.880
AP4E1
AP-4 complex subunit epsilon; AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system; Belongs to the adaptor complexes large subunit family.
   
 0.871
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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