node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APEX1 | FEN1 | ENSLACP00000009774 | ENSLACP00000001751 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.928 |
APEX1 | H2ZWI5_LATCH | ENSLACP00000009774 | ENSLACP00000001756 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Uncharacterized protein. | 0.485 |
APEX1 | H3ALV1_LATCH | ENSLACP00000009774 | ENSLACP00000010622 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Uncharacterized protein. | 0.987 |
APEX1 | MRE11 | ENSLACP00000009774 | ENSLACP00000004618 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.487 |
APEX1 | PCNA | ENSLACP00000009774 | ENSLACP00000006575 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.870 |
APEX1 | POLD1 | ENSLACP00000009774 | ENSLACP00000017387 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA polymerase. | 0.722 |
APEX1 | POLE | ENSLACP00000009774 | ENSLACP00000019593 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.741 |
APEX1 | RFC2 | ENSLACP00000009774 | ENSLACP00000021161 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Replication factor C subunit 2. | 0.683 |
APEX1 | RFC4 | ENSLACP00000009774 | ENSLACP00000020302 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Replication factor C subunit 4. | 0.744 |
DNA2 | FEN1 | ENSLACP00000015503 | ENSLACP00000001751 | DNA replication helicase/nuclease 2. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.932 |
DNA2 | H2ZWI5_LATCH | ENSLACP00000015503 | ENSLACP00000001756 | DNA replication helicase/nuclease 2. | Uncharacterized protein. | 0.995 |
DNA2 | H3ALV1_LATCH | ENSLACP00000015503 | ENSLACP00000010622 | DNA replication helicase/nuclease 2. | Uncharacterized protein. | 0.776 |
DNA2 | MRE11 | ENSLACP00000015503 | ENSLACP00000004618 | DNA replication helicase/nuclease 2. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.936 |
DNA2 | PCNA | ENSLACP00000015503 | ENSLACP00000006575 | DNA replication helicase/nuclease 2. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.887 |
DNA2 | POLD1 | ENSLACP00000015503 | ENSLACP00000017387 | DNA replication helicase/nuclease 2. | DNA polymerase. | 0.972 |
DNA2 | POLE | ENSLACP00000015503 | ENSLACP00000019593 | DNA replication helicase/nuclease 2. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.860 |
DNA2 | RFC2 | ENSLACP00000015503 | ENSLACP00000021161 | DNA replication helicase/nuclease 2. | Replication factor C subunit 2. | 0.745 |
DNA2 | RFC4 | ENSLACP00000015503 | ENSLACP00000020302 | DNA replication helicase/nuclease 2. | Replication factor C subunit 4. | 0.836 |
FEN1 | APEX1 | ENSLACP00000001751 | ENSLACP00000009774 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 0.928 |
FEN1 | DNA2 | ENSLACP00000001751 | ENSLACP00000015503 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA replication helicase/nuclease 2. | 0.932 |