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FEN1 protein (Latimeria chalumnae) - STRING interaction network
"FEN1" - Flap structure-specific endonuclease 1 in Latimeria chalumnae
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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FEN1Flap structure-specific endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminat [...] (317 aa)    
Predicted Functional Partners:
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (260 aa)
     
  0.998
WRN
Werner syndrome, RecQ helicase-like (1469 aa)
   
  0.963
ENSLACG00000001792
Uncharacterized protein (360 aa)
   
  0.957
MSH2
Uncharacterized protein (447 aa)
   
  0.957
MRE11A
MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (710 aa)
     
  0.952
DNA2
DNA replication helicase 2 homolog (yeast) (925 aa)
   
  0.946
RFC4
Replication factor C (activator 1) 4, 37kDa (360 aa)
     
  0.946
RECQL
RecQ protein-like (DNA helicase Q1-like) (644 aa)
   
  0.941
BLM
Bloom syndrome, RecQ helicase-like (1450 aa)
   
  0.941
FANCM
Fanconi anemia, complementation group M (2075 aa)
     
  0.918
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: Actinistia, Choanichthyes, Coelacanthidae, Coelacanthiformes, Coelacanthimorpha, Crossopterygii, L. chalumnae, Latimeria, Latimeria chalumnae, Latimeriidae, coelacanth, coelacanths, lobe-finned fishes
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