STRINGSTRING
WRN protein (Latimeria chalumnae) - STRING interaction network
"WRN" - Werner syndrome, RecQ helicase-like in Latimeria chalumnae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WRNWerner syndrome, RecQ helicase-like (1469 aa)    
Predicted Functional Partners:
ATR
Ataxia telangiectasia and Rad3 related (2654 aa)
     
  0.987
FANCM
Fanconi anemia, complementation group M (2075 aa)
     
  0.985
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6 (610 aa)
     
 
  0.983
EXO1
Exonuclease 1 (805 aa)
   
  0.976
XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) (606 aa)
     
 
  0.974
WRNIP1
Uncharacterized protein (344 aa)
     
 
  0.973
ENSLACG00000000498
Werner helicase interacting protein 1 (250 aa)
     
 
  0.973
TOP3B
Topoisomerase (DNA) III beta; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (863 aa)
     
  0.970
TOP3A
Topoisomerase (DNA) III alpha; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (999 aa)
     
  0.970
RPA1
Replication protein A1, 70kDa (495 aa)
     
  0.968
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: Actinistia, Choanichthyes, Coelacanthidae, Coelacanthiformes, Coelacanthimorpha, Crossopterygii, L. chalumnae, Latimeria, Latimeria chalumnae, Latimeriidae, coelacanth, coelacanths, lobe-finned fishes
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