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STRINGSTRING
MAPK14 protein (Latimeria chalumnae) - STRING interaction network
"MAPK14" - Mitogen-activated protein kinase 14 in Latimeria chalumnae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAPK14Mitogen-activated protein kinase 14 (399 aa)    
Predicted Functional Partners:
MAPKAPK2
Mitogen-activated protein kinase-activated protein kinase 2a (332 aa)
   
0.980
MAP2K6
Mitogen-activated protein kinase kinase 6 (332 aa)
   
0.965
MAP2K3
Mitogen-activated protein kinase kinase 3 (338 aa)
   
0.965
MAPKAPK3
Mitogen-activated protein kinase-activated protein kinase 3 (386 aa)
   
0.965
JUN
Jun proto-oncogene, AP-1 transcription factor subunit; Jun proto-oncogene (311 aa)
     
  0.954
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family (401 aa)
       
  0.937
ATF2
Activating transcription factor 2 (495 aa)
       
  0.925
ENSLACG00000000049
Uncharacterized protein; Activating transcription factor 2 (172 aa)
       
  0.925
FOS
Fos proto-oncogene, AP-1 transcription factor subunit; V-fos FBJ murine osteosarcoma viral oncogene homolog (391 aa)
       
  0.922
FOXO3
Forkhead box O3 (661 aa)
     
  0.920
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, Latimeria chalumnae, coelacanth
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