MSRA protein (Latimeria chalumnae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

MSRA

Methionine sulfoxide reductase A. (214 aa)

Predicted Functional Partners:

MSRB2

0.966

LOC102354290

0.878

LOC102347712

0.871

M3XI97_LATCH

0.844

TXN2

0.841

DNAJC10

0.756

MSRB1

0.749

H3B037_LATCH

0.673

GLRX2

0.668

LOC102347122

0.633

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNAJC10	H3B037_LATCH	ENSLACP00000002171	ENSLACP00000015258	DnaJ heat shock protein family (Hsp40) member C10.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.426
DNAJC10	LOC102347712	ENSLACP00000002171	ENSLACP00000002294	DnaJ heat shock protein family (Hsp40) member C10.	Thioredoxin; Belongs to the thioredoxin family.	0.464
DNAJC10	LOC102354290	ENSLACP00000002171	ENSLACP00000003364	DnaJ heat shock protein family (Hsp40) member C10.	Uncharacterized protein.	0.768
DNAJC10	M3XI97_LATCH	ENSLACP00000002171	ENSLACP00000022453	DnaJ heat shock protein family (Hsp40) member C10.	Thioredoxin domain-containing protein.	0.464
DNAJC10	MSRA	ENSLACP00000002171	ENSLACP00000001797	DnaJ heat shock protein family (Hsp40) member C10.	Methionine sulfoxide reductase A.	0.756
DNAJC10	MSRB1	ENSLACP00000002171	ENSLACP00000013022	DnaJ heat shock protein family (Hsp40) member C10.	Methionine sulfoxide reductase B1.	0.579
DNAJC10	MSRB2	ENSLACP00000002171	ENSLACP00000016069	DnaJ heat shock protein family (Hsp40) member C10.	Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.	0.579
GLRX2	H3B037_LATCH	ENSLACP00000000117	ENSLACP00000015258	Glutaredoxin 2.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.470
GLRX2	LOC102347712	ENSLACP00000000117	ENSLACP00000002294	Glutaredoxin 2.	Thioredoxin; Belongs to the thioredoxin family.	0.647
GLRX2	LOC102354290	ENSLACP00000000117	ENSLACP00000003364	Glutaredoxin 2.	Uncharacterized protein.	0.600
GLRX2	M3XI97_LATCH	ENSLACP00000000117	ENSLACP00000022453	Glutaredoxin 2.	Thioredoxin domain-containing protein.	0.620
GLRX2	MSRA	ENSLACP00000000117	ENSLACP00000001797	Glutaredoxin 2.	Methionine sulfoxide reductase A.	0.668
GLRX2	MSRB2	ENSLACP00000000117	ENSLACP00000016069	Glutaredoxin 2.	Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.	0.403
GLRX2	TXN2	ENSLACP00000000117	ENSLACP00000003526	Glutaredoxin 2.	Thioredoxin 2.	0.716
H3B037_LATCH	DNAJC10	ENSLACP00000015258	ENSLACP00000002171	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	DnaJ heat shock protein family (Hsp40) member C10.	0.426
H3B037_LATCH	GLRX2	ENSLACP00000015258	ENSLACP00000000117	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Glutaredoxin 2.	0.470
H3B037_LATCH	LOC102347712	ENSLACP00000015258	ENSLACP00000002294	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Thioredoxin; Belongs to the thioredoxin family.	0.775
H3B037_LATCH	LOC102354290	ENSLACP00000015258	ENSLACP00000003364	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Uncharacterized protein.	0.455
H3B037_LATCH	M3XI97_LATCH	ENSLACP00000015258	ENSLACP00000022453	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Thioredoxin domain-containing protein.	0.477
H3B037_LATCH	MSRA	ENSLACP00000015258	ENSLACP00000001797	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Methionine sulfoxide reductase A.	0.673

page 1 of 4

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.0522

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0099560

Synaptic membrane adhesion

5 of 12

2.84

4.76

1.30e-09

GO:0035335

Peptidyl-tyrosine dephosphorylation

4 of 27

2.39

2.73

5.75e-06

GO:0019221

Cytokine-mediated signaling pathway

6 of 181

1.74

2.39

1.81e-06

GO:0097374

Sensory neuron axon guidance

2 of 4

2.92

1.36

0.0035

GO:0070498

interleukin-1-mediated signaling pathway

2 of 7

2.68

1.21

0.0062

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004908

interleukin-1 receptor activity

4 of 4

3.22

4.35

1.23e-08

GO:0061809

NAD+ nucleotidase, cyclic ADP-ribose generating

3 of 15

2.52

2.13

0.00011

GO:0050135

NAD(P)+ nucleosidase activity

3 of 15

2.52

2.13

0.00011

GO:0004725

Protein tyrosine phosphatase activity

4 of 97

1.84

1.86

0.00011

GO:0008201

Heparin binding

4 of 114

1.77

1.75

0.00016

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34025644

(2021) Modeling Virus-Induced Inflammation in Zebrafish: A Balance Between Infection Control and Excessive Inflammation.

3 of 39

2.11

1.48

0.0014

PMID:27231948

(2016) The Function of Fish Cytokines.

3 of 40

2.1

1.48

0.0014

PMID:35371107

(2022) Transcriptome Sequencing Reveals the Antiviral Innate Immunity by IFN-gamma in Chinese Sturgeon Macrophages.

2 of 12

2.44

1.16

0.0075

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4439

NAD+ nucleosidase activity, and interleukin-1-mediated signaling pathway

6 of 17

2.77

6.02

3.38e-12

CL:4443

interleukin-1-mediated signaling pathway, and Inflammatory response

4 of 5

3.13

4.47

6.78e-09

CL:7095

Receptor-type tyrosine-protein phosphatases, and Synaptic membrane adhesion

4 of 21

2.5

3.38

3.39e-07

CL:7097

Synaptic membrane adhesion, and Presynaptic membrane assembly

3 of 13

2.59

2.46

2.65e-05

CL:7099

Synaptic membrane adhesion, and NTF3 activates NTRK3 signaling

2 of 5

2.82

1.53

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04520

Adherens junction

4 of 105

1.8

1.9

7.30e-05

map04910

Insulin signaling pathway

4 of 157

1.63

1.68

0.00012

map04620

Toll-like receptor signaling pathway

3 of 91

1.74

1.49

0.00067

map04514

Cell adhesion molecules

4 of 210

1.5

1.46

0.00027

map04010

MAPK signaling pathway

5 of 361

1.36

1.41

0.00012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-388844

Receptor-type tyrosine-protein phosphatases

5 of 24

2.54

4.43

2.60e-09

MAP-446652

Interleukin-1 family signaling

7 of 108

2.03

4.21

1.69e-10

MAP-8849932

Synaptic adhesion-like molecules

4 of 21

2.5

3.37

3.63e-07

MAP-6794362

Protein-protein interactions at synapses

5 of 89

1.97

2.89

4.72e-07

MAP-9020702

Interleukin-1 signaling

5 of 95

1.94

2.83

5.39e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0904

Protein phosphatase

3 of 70

1.85

1.25

0.0032

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004074

Interleukin-1 receptor type I/II

4 of 7

2.98

3.72

1.52e-07

IPR015621

Interleukin-1 receptor family

4 of 10

2.82

3.59

2.31e-07

IPR000157

Toll/interleukin-1 receptor homology (TIR) domain

3 of 29

2.24

1.68

0.00065

IPR035897

Toll/interleukin-1 receptor homology (TIR) domain superfamily

3 of 31

2.21

1.65

0.00070

IPR003598

Immunoglobulin subtype 2

5 of 245

1.53

1.52

0.00021

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00194

Protein tyrosine phosphatase, catalytic domain

3 of 39

2.11

1.59

0.00085

SM00409

Immunoglobulin

5 of 351

1.38

1.2

0.00085

SM00255

Toll - interleukin 1 - resistance

2 of 14

2.38

1.09

0.0098

SM00408

Immunoglobulin C-2 Type

3 of 206

1.39

0.67

0.0378

SM00060

Fibronectin type 3 domain

3 of 198

1.4

0.67

0.0378

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