Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FOXP2-2Uncharacterized protein. (66 aa)    
Predicted Functional Partners:
FOXP4
Forkhead box P4.
    
 
 0.809
TBR1
T-box brain transcription factor 1.
    
 
 0.652
CUX1
Homeobox protein cut-like.
    
 
 0.592
MAMLD1
Mastermind like domain containing 1.
      
 0.571
MED8
Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
      
 0.566
TFB2M
rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
      
 0.559
WDR5B
WD repeat domain 5B.
      
 0.555
SOX5
SRY-box transcription factor 5.
    
 
 0.550
ZNF236
Zinc finger protein 236.
    
 0.546
H3AV84_LATCH
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor.
    
 
 0.544
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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