Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1184 aa)    
Predicted Functional Partners:
KCNE4
Potassium voltage-gated channel subfamily E regulatory subunit 4.
     
 0.615
GJA5
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
      
 0.588
KCNJ8
Potassium voltage-gated channel subfamily J member 8.
      
 0.584
SHOX2
Short stature homeobox 2.
    
 
 0.572
ISL1
ISL LIM homeobox 1.
      
 0.571
CACNA1G
Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]
   
 
 0.561
H3AFD4_LATCH
Cyclic nucleotide-binding domain-containing protein.
  
  
 
0.560
KCNE2
Potassium voltage-gated channel subfamily E regulatory subunit 2.
    
 0.560
NKX2-5
NK2 homeobox 5.
   
  
 0.559
LOC102347888
Cyclic nucleotide-binding domain-containing protein.
  
  
 
0.552
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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