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IGFBP3 protein (Latimeria chalumnae) - STRING interaction network
"IGFBP3" - Insulin-like growth factor binding protein 3 in Latimeria chalumnae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IGFBP3Insulin-like growth factor binding protein 3 (288 aa)    
Predicted Functional Partners:
IGF1
Insulin-like growth factor 1 (somatomedin C) (136 aa)
       
  0.979
IGF2
Insulin-like growth factor 2 (somatomedin A) (207 aa)
     
  0.865
IGFALS
Insulin-like growth factor binding protein, acid labile subunit (605 aa)
       
  0.734
TP53
Tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (401 aa)
         
  0.662
PLG
Plasminogen (725 aa)
       
  0.658
ENSLACG00000006484
Uncharacterized protein ; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (111 aa)
           
  0.640
F2
Coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (618 aa)
     
  0.604
ENSLACG00000014891
Uncharacterized protein (586 aa)
       
  0.598
MMP2
Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (653 aa)
     
  0.586
MMP9
Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (682 aa)
     
  0.586
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: Actinistia, Choanichthyes, Coelacanthidae, Coelacanthiformes, Coelacanthimorpha, Crossopterygii, L. chalumnae, Latimeria, Latimeria chalumnae, Latimeriidae, coelacanth, coelacanths, lobe-finned fishes
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