close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DLX5Distal-less homeobox 5. (290 aa)    
Predicted Functional Partners:
DLX6
Distal-less homeobox 6.
  
 
0.838
BMP4
Bone morphogenetic protein 4.
     
 0.638
HAND2
Heart and neural crest derivatives expressed 2.
      
 0.596
EDN1
Endothelin 1.
      
 0.592
EDNRA
Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.590
RUNX2
Runt-related transcription factor.
   
 
 0.588
MSX2
Msh homeobox 2.
   
0.581
MYF6
Myogenic factor 6.
   
  
 0.539
FGF8
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
      
 0.534
FOXG1
Forkhead box G1.
   
 
 0.506
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.