Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Coagulation factor VII (serum prothrombin conversion accelerator) (439 aa)
Predicted Functional Partners:
Coagulation factor III (thromboplastin, tissue factor) (286 aa)
Coagulation factor IX (453 aa)
Coagulation factor X (475 aa)
Serpin peptidase inhibitor, clade C (antithrombin), member 1 (485 aa)
Gamma-glutamyl carboxylase (684 aa)
Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (403 aa)
Von Willebrand factor (2833 aa)
Tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (401 aa)