Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
DNA nucleotidylexotransferase (487 aa)
Predicted Functional Partners:
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (260 aa)
Ligase IV, DNA, ATP-dependent (911 aa)
Caspase 3, apoptosis-related cysteine protease a; Belongs to the peptidase C14A family (290 aa)
Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family (457 aa)
Annexin A5b (349 aa)
STARD3 N-terminal like (234 aa)
X-ray repair complementing defective repair in Chinese hamster cells 6 (610 aa)
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand
STARD3 N-terminal like
X-ray repair complementing defective repair in Chinese hamster cells 6
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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
For the above enrichment analysis, the following statistical background is assumed: