Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
H2ZXR2_LATCHLigase III, DNA, ATP-dependent; Belongs to the ATP-dependent DNA ligase family. (960 aa)    
Predicted Functional Partners:
H3AC16_LATCH
X-ray repair complementing defective repair in Chinese hamster cells 1.
   
 0.994
POLB
DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
  
 0.994
PNKP
Polynucleotide kinase 3'-phosphatase.
   
 0.984
TDP1
Tyrosyl-DNA phosphodiesterase 1.
   
 
 0.967
XRCC6
X-ray repair cross complementing 6.
   
 0.962
APLF
FHA_2 domain-containing protein.
    
 
 0.962
LOC102360939
XRCC1_N domain-containing protein.
   
 0.929
RACGAP1
Rac GTPase activating protein 1.
   
   0.918
RNF146
Ring finger protein 146.
    
 
 0.917
PARP2
Poly [ADP-ribose] polymerase.
   
 
 0.915
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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